Recombinant Human HMOX2

• Cat.No.: HMOX2-27003TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-264 of Human Heme oxygenase 2; 264 amino acids, MWt 30.5 kDa.

Specification

• Description: Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Alternative splice variants encoding the same protein have been identified at this locus.
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MSAEVETSEG VDESEKKNSG ALEKENQMRM ADLSELLKEG TKEAHDRAEN TQFVKDFLKG NIKKELFKLA TTALYFTYSA LEEEMERNKD HPAFAPLYFP MELHRKEALT KDMEYFFGEN WEEQVQCPKA AQKYVERIHY IGQNEPELLV AHAYTRYMGD LSGGQVLKKV AQRALKLPST GEGTQFYLFE NVDNAQQFKQ LYRARMNALD LNMKTKERIV EEANKAFEYN MQIFNELDQA GSTLARETLE DGFPVHDGKG DMRK
• Sequence Similarities: Belongs to the heme oxygenase family.Contains 2 HRM (heme regulatory motif) repeats.

Gene Information

• Gene Name: HMOX2 heme oxygenase (decycling) 2 [ Homo sapiens ]
• Official Symbol: HMOX2
• Synonyms: HMOX2; heme oxygenase (decycling) 2; heme oxygenase 2; HO 2
• Gene ID: 3163
• mRNA Refseq: NM_001127204
• Protein Refseq: NP_001120676
• MIM: 141251
• Uniprot ID: P30519
• Chromosome Location: 16p13.3
• Pathway: Heme degradation, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of porphyrins, organism-specific biosystem; Mineral absorption, organism-specific biosystem
• Function: electron carrier activity; heme oxygenase (decyclizing) activity; metal ion binding; oxidoreductase activity; protein binding