"HPRT1" Related Products

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Recombinant Human HPRT1, His-tagged

Cat.No.: HPRT1-28755TH
Product Overview: Recombinant full length Human HPRT with an N-terminal His tag; 238 amino acids with a predicted MWt 26.7 kDa including tag.
Description: The protein encoded by this gene is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway. Mutations in this gene result in Lesch-Nyhan syndrome or gout.
Protein length: 218 amino acids
Conjugation: HIS
Molecular Weight: 26.700kDa inclusive of tags
Source: E. coli
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: pH: 8.00Constituents:0.32% Tris HCl, 20% Glycerol
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MATRSPGVVI SDDEPGYDLD LFCIPNHYAE DLERVFIPHG LIMDRTERLA RDVMKEMGGH HIVALCVLKG GYKFFADLLD YIKALNRNSD RSIPMTVDFI RLKSYCNDQS TGDIKVIGGD DLSTLTGKNV LIVEDIIDTG KTMQTLLSLV RQYNPKMVKV ASLLVKRTPR SVGYKPDFVG FEIPDKFVVG YALDYNEYFR DLNHVCVISE TGKAKYKA
Sequence Similarities: Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Gene Name: HPRT1 hypoxanthine phosphoribosyltransferase 1 [ Homo sapiens ]
Official Symbol: HPRT1
Synonyms: HPRT1; hypoxanthine phosphoribosyltransferase 1; HPRT; hypoxanthine-guanine phosphoribosyltransferase; HGPRT; Lesch Nyhan syndrome;
Gene ID: 3251
mRNA Refseq: NM_000194
Protein Refseq: NP_000185
MIM: 308000
Uniprot ID: P00492
Chromosome Location: Xq26.2
Pathway: Drug metabolism - other enzymes, organism-specific biosystem; Drug metabolism - other enzymes, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem;
Function: guanine phosphoribosyltransferase activity; hypoxanthine phosphoribosyltransferase activity; hypoxanthine phosphoribosyltransferase activity; magnesium ion binding; nucleotide binding;

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