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Recombinant Human Fms-related Tyrosine Kinase 3

Cat.No. : FLT3-494H
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Cat. No. : FLT3-494H
Description : Fms-Like tyrosine kinase 3 (FLT3) is a member of the class III tyrosine kinase receptor family, normally expressed in hematopoietic, immune and neural systems. FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin. FLT3 is a promising target for the therapeutic intervention for acute leukemias, particularly acute myeloid leukemia (AML) which are severe and aggressive malignancy.
Molecular Weight : The predicted molecular weight of Recombinant Human Flt-3 is Mr 85.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 120 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >97% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : FLT3 fms-related tyrosine kinase 3 [ Homo sapiens ]
Synonyms : FLT3; fms-related tyrosine kinase 3; FLK2; STK1; CD135; FLT3; CD135 antigen; FL cytokine receptor; fetal liver kinase 2; stem cell tyrosine kinase 1; FLT3 receptor tyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factor receptor tyrosine kinase type III
Gene ID : 2322
mRNA Refseq : NM_004119
Protein Refseq : NP_004110
MIM : 136351
UniProt ID : P36888
Chromosome Location : 13q12
Pathway : Cytokine-cytokine receptor interaction; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage; Pathways in cancer
Function : ATP binding; nucleotide binding; phosphoinositide 3-kinase binding; protein binding; receptor activity; transferase activity; vascular endothelial growth factor receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is FLT3 implicated in acute myeloid leukemia (AML)? 12/24/2021

FLT3 is frequently mutated in AML, contributing to uncontrolled cell growth and poor prognosis.

In which cells or tissues is FLT3 predominantly expressed? 07/08/2021

FLT3 is predominantly expressed in hematopoietic stem cells and progenitor cells.

How does FLT3 contribute to hematopoiesis? 03/15/2021

It is essential for hematopoiesis, particularly in the proliferation of early progenitor cells.

Are there therapeutic strategies targeting FLT3 for disease treatment? 08/01/2020

Therapeutic strategies include FLT3 inhibitors, showing effectiveness in treating AML patients with FLT3 mutations.

What is the primary biological function of FLT3 in cells? 06/27/2020

FLT3 is a receptor tyrosine kinase that plays a crucial role in cell survival, proliferation, and differentiation.

What role does FLT3 play in the proliferation and differentiation of hematopoietic stem cells? 07/14/2019

It stimulates the proliferation and differentiation of hematopoietic stem cells, guiding their development into various blood cell types.

What are the common mutations found in FLT3 associated with diseases? 04/05/2019

Common mutations include internal tandem duplications (ITD) and tyrosine kinase domain (TKD) mutations, leading to constitutive activation of FLT3.

Customer Reviews (3)

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Reviews
08/01/2021

    Excellent product, great price.

    12/22/2020

      Satisfied, will order again.

      09/14/2020

        Quick response, helpful service.

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