Recombinant Human HSP90AA1, His-tagged
Cat.No. : | HSP90AA1-27844TH |
Product Overview : | Recombinant full length Human Hsp90 alpha with C-terminal His tag, 85.5 kDa. |
- Specification
- Gene Information
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Description : | HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al. |
Conjugation : | HIS |
Source : | E. coli |
Biological activity : | Specific Activity : Kd of 8 nM.Assay conditions : 95 ul reaction mix (20 mM HEPES pH7.3, 50 mM KCl, 5 mM MgCl2, 20 mM Na2MoO4, 0.01% Triton X- 100, 100 ug/ml bovine serum albumin, 2 mM DTT, 0-30 nM Hsp90alpha) + 5 ul FITCgeldanamycin, incubate for 4 hrs a |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 0.05% Tween 20, 400mM Sodium chloride, 3mM DTT, 25mM Tris HCl, pH 7.5 |
Storage : | Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the heat shock protein 90 family. |
Gene Name : | HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 [ Homo sapiens ] |
Official Symbol : | HSP90AA1 |
Synonyms : | HSP90AA1; heat shock protein 90kDa alpha (cytosolic), class A member 1; heat shock 90kD protein 1, alpha , heat shock 90kDa protein 1, alpha , HSPC1, HSPCA; heat shock protein HSP 90-alpha; FLJ31884; Hsp89; Hsp90; HSP90N; |
Gene ID : | 3320 |
mRNA Refseq : | NM_001017963 |
Protein Refseq : | NP_001017963 |
MIM : | 140571 |
Uniprot ID : | P07900 |
Chromosome Location : | 14q32.33 |
Pathway : | Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Axon guidance, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; |
Function : | ATP binding; ATP binding; ATPase activity; TPR domain binding; TPR domain binding; |
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◆ Native Protein | ||
HSP90AA1-14H | Native Hsp90 Protein | +Inquiry |
◆ Lysates | ||
HSP90AA1-5362HCL | Recombinant Human HSP90AA1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionHSP90AA1 proteins can participate in regulating the expression and function of inflammatory factors in the inflammatory process, which has an impact on the occurrence and development of inflammatory diseases.
HSP90AA1 proteins can help immune cells fold and activate some important antigens, participate in the immune response process, and have an impact on tumor immunotherapy.
The expression level of HSP90AA1 protein is upregulated in some tumor cells and can serve as a potential tumor biomarker for tumor diagnosis and monitoring.
There is no clear evidence that HSP90AA1 protein can be used as a therapeutic target for inflammatory diseases, but its regulatory role in the inflammatory process may provide new ideas for the development of related therapeutic strategies.
HSP90AA1 proteins can lead to the occurrence and development of tumor drug resistance by stabilizing and protecting some resistance-related proteins, such as ABC transporters.
Inhibitors targeting HSP90AA1 proteins can be developed to interfere with their interactions with other proteins, affecting the growth and survival of tumor cells.
Customer Reviews (3)
Write a reviewThis powerful biological activity of the protein combined with its high purity makes the experimental results extremely reliable.
Application range of this protein is really wide, from the laboratory to the clinic, can see its figure, it is really rare.
Short half-life and high clearance of recombinant proteins enable them to effectively avoid drug accumulation and side effects, and provide a strong guarantee for patient safety.
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