Recombinant Human HSP90AA1 protein, His-tagged

• Cat.No.: HSP90AA1-28997TH
• Product Overview: Recombinant Human HSP90AA1 fussed with His tag at C-terminal was expressed in Sf9 insect cells using baculovirus.

Specification

• Description: HSP90α is a member of the HSP90 family of proteins which are important molecular chaperones involved in signal transduction, cell cycle control, stress management, folding, degradation, and transport of proteins. HSP90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, including HER2/ERBB2, AKT, RAF1, BCR-ABL and mutated p53. HSP90 inhibitors bind to HSP90, and induce the proteasomal degradation of HSP90 client proteins. HSP90α is an important mediator of cancer cell invasion and is expressed extracellularly on fibrosarcoma and breast cancer cells where it interacts with MMP2.
• Source: Insect cells
• Species: Human
• Tag: His
• Form: 50mM MOPS, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
• Molecular Mass: ~94 kDa
• Purity: > 85%
• Applications: Western Blot
• Stability: One year at –70 centigrade from date of shipment
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.2 ug/ul

Gene Information

• Gene Name: HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 [ Homo sapiens ]
• Official Symbol: HSP90AA1
• Synonyms: EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4; heat shock protein HSP 90-alpha; HSP 86; LPS-associated protein 2; epididymis luminal secretory protein 52; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; lipopolysaccharide-associated protein 2; renal carcinoma antigen NY-REN-38
• Gene ID: 3320
• mRNA Refseq: NM_005348
• Protein Refseq: NP_005339
• MIM: 140571
• UniProt ID: P07900
• Chromosome Location: 14q32.33
• Pathway: AhR pathway, organism-specific biosystem; Anchoring of the basal body to the plasma membrane, organism-specific biosystem; Assembly of the primary cilium, organism-specific biosystem
• Function: ATP binding; ATPase activity; TPR domain binding