"GFRA1" Related Products

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Recombinant Human GDNF Family Receptor Alpha 1

Cat. No.: GFRA1-1618H
Description: GDNF family receptor alpha 1, also known as GFRA1 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRalpha1 functions as a ligand-induced cell adhesion molecule (LICAM) to establish precise synaptic contacts and induce presynaptic differentiation.
Source: NSO cells.
Molecular Weight: The predicted molecular weight of Recombinant Human GFRα-1 is 73.3 kDa. However, the actual molecular weight as observed by migration on SDS Page is 88-95 kDa.
State Of Matter: Lyophilized.
Purity: >90% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Biological Activity: The biological activity of Human GFRα-1 was determined by its ability to bind recombinant human GDNF. Immobilized recombinant human GFRα-1/Fc at 2 μg/ml (100 μl/well) can bind recombinant human GDNF with a linear range at 0.78 - 5 ng/ml in a functional ELISA assay.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: GFRA1 GDNF family receptor alpha 1 [ Homo sapiens ]
Synonyms: GFRA1; GDNF family receptor alpha 1; Gfra1; glial cell line derived neurotrophic factor family receptor alpha 1; AU042498; GDNFR-alpha; GFR alpha-1
Gene ID: 2674
mRNA Refseq: NM_001145453
Protein Refseq: NP_001138925
MIM: 601496
UniProt ID: P56159
Chromosome Location: 10q26.11
Pathway: Axon guidance
Function: glial cell line-derived neurotrophic factor receptor activity; receptor activity; receptor binding

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