||GDNF family receptor alpha 1, also known as GFRA1 is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. GFRalpha1 functions as a ligand-induced cell adhesion molecule (LICAM) to establish precise synaptic contacts and induce presynaptic differentiation.
||The predicted molecular weight of Recombinant Human GFRα-1 is 73.3 kDa. However, the actual molecular weight as observed by migration on SDS Page is 88-95 kDa.
|State Of Matter:
||>90% by SDS Page and analyzed by silver stain.
||<1.0 EU/µg as determined by the LAL method.
||The biological activity of Human GFRα-1 was determined by its ability to bind recombinant human GDNF. Immobilized recombinant human GFRα-1/Fc at 2 μg/ml (100 μl/well) can bind recombinant human GDNF with a linear range at 0.78 - 5 ng/ml in a functional ELISA assay.
||This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.