Active Recombinant Human GHR Protein, Fc-tagged
Cat.No. : | GHR-1623H |
Product Overview : | Recombinant Human GHR (Ala27-Tyr264) with Human IgG1 (Pro100-Lys330) Fc tag was expressed in Mouse myeloma cell line. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene. |
Source : | Mouse myeloma cell line |
Species : | Human |
Tag : | Fc |
Form : | Disulfide-linked homodimer |
Bio-activity : | Measured by its ability to inhibit GH-induced proliferation of Nb2-11 rat lymphoma cells. The ED50 for this effect is 0.4-2.0 ng/mL in the presence of 0.2 ng/mL of rhGH. |
Molecular Mass : | 54 kDa (monomer) |
Protein length : | 27-264 |
N-terminal Sequence Analysis : | Ala27 |
Endotoxin : | < 0.01 EU/μg of the protein by the LAL method. |
Purity : | > 90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Storage Buffer : | Lyophilized from a 0.2 μm filtered solution in PBS. |
Reconstitution : | Reconstitute at 100 μg/mL in sterile PBS. |
Shipping : | The product is shipped at ambient temperature. |
Gene Name : | GHR growth hormone receptor [ Homo sapiens (human) ] |
Official Symbol : | GHR |
Synonyms : | GHR; growth hormone receptor; GHBP; GHIP; growth hormone receptor; GH receptor; growth hormone binding protein; mutant growth hormone receptor; serum binding protein; somatotropin receptor; truncated growth hormone receptor |
Gene ID : | 2690 |
mRNA Refseq : | NM_000163 |
Protein Refseq : | NP_000154 |
MIM : | 600946 |
UniProt ID : | P10912 |
Products Types
◆ Recombinant Protein | ||
GHR-555H | Recombinant Human GHR Protein, Biotinylated | +Inquiry |
GHR-1279R | Acitve Recombinant Rat GHR protein(Met1-Arg265), hFc-tagged | +Inquiry |
Ghr-3269M | Active Recombinant Mouse Ghr protein(Met1-Gln273), His-tagged | +Inquiry |
GHR-1226H | Recombinant Human GHR Protein, His-SUMO-tagged | +Inquiry |
GHR-279H | Recombinant Human GHR Protein, His-tagged | +Inquiry |
◆ Lysates | ||
GHR-2401MCL | Recombinant Mouse GHR cell lysate | +Inquiry |
GHR-1140RCL | Recombinant Rat GHR cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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