"IDO1" Related Products

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Recombinant Human IDO1

Cat.No.: IDO1-28269TH
Product Overview: Recombinant full length Human Indoleamine 2, 3-dioxygenase protein with an N terminal proprietary tag; predicted Mwt: 70.07 kDa
Description: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
Protein length: 403 amino acids
Molecular Weight: 70.070kDa inclusive of tags
Source: Wheat germ
Form: Liquid
Purity: Proprietary Purification
Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequences of amino acids: MAHAMENSWT ISKEYHIDEE VGFALPNPQE NLPDFYNDWM FIAKHLPDLI ESGQLRERVE KLNMLSIDHL TDHKSQRLAR LVLGCITMAY VWGKGHGDVR KVLPRNIAVP YCQLSKKLEL PPILVYADCV LANWKKKDPN KPLTYENMDV LFSFRDGDCS KGFFLVSLLV EIAAASAIKV IPTVFKAMQM QERDTLLKAL LEIASCLEKA LQVFHQIHDH VNPKAFFSVL RIYLSGWKGN PQLSDGLVYE GFWEDPKEFA GGSAGQSSVF QCFDVLLGIQ QTAGGGHAAQ FLQDMRRYMP PAHRNFLCSL ESNPSVREFV LSKGDAGLRE AYDACVKALV SLRSYHLQIV TKYILIPASQ QPKENKTSED PSKLEAKGTG GTDLMNFLKT VRSTTEKSLL KEG
Sequence Similarities: Belongs to the indoleamine 2,3-dioxygenase family.
Gene Name: IDO1 indoleamine 2,3-dioxygenase 1 [ Homo sapiens ]
Official Symbol: IDO1
Synonyms: IDO1; indoleamine 2,3-dioxygenase 1; IDO, INDO, indoleamine pyrrole 2,3 dioxygenase;
Gene ID: 3620
mRNA Refseq: NM_002164
Protein Refseq: NP_002155
MIM: 147435
Uniprot ID: P14902
Chromosome Location: 8p12-p11
Pathway: African trypanosomiasis, organism-specific biosystem; African trypanosomiasis, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem;
Function: electron carrier activity; heme binding; indoleamine 2,3-dioxygenase activity; metal ion binding; oxidoreductase activity;

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