Recombinant Human IFNGR1, Fc-tagged
Cat.No. : | IFNGR1-28503TH |
Product Overview : | Recombinant fragment, corresponding to the extracellular domain (amino acids 18-245) of Human IFNGR1 fused to the Fc region of Human IgG1 (aa 93-330). The chimeric protein was expressed in modified Human 293 cells. |
- Specification
- Gene Information
- Related Products
Description : | This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. |
Conjugation : | Fc |
Biological activity : | The ED50 of IFNGR1 (Fc Chimera) is typically 0.05-0.1 μg/ml as measured by its ability to neutralize IFN gamma mediated cytotoxicity using the HT-29 colorectal adenocarcinoma cell line. |
Form : | Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin |
Storage : | Store at +4°C. |
Sequences of amino acids : | Theoretical sequence: EMGTADLGPSSVPTPTNVTIESYNM NPIVYWEYQIMPQ VPVFTVEVKNYGVKNSEWIDACINI SHHYCNISDHVGD PSNSLWVRVKARVGQKESAYAKSEE FAVCRDGKIGPPK LDIRKEEKQIMIDIFHPSVFVNGDE QEVDYDPETTCYI RVYNVYVRMNGSEIQYKILTQKEDD CDEIQCQLAIPVSSLNSQYCVSAEG VLHVWGVTTEKSKEVCITIFNSSIK GGS SNTKVDKKVEPKSCDKTHTCPPCPA PELLGGPSVFLFP PKPKDTLMISRTPEVTCVVVDVSHE DPEVKFNWYVDGV EVHNAKTKPREEQYNSTYRVVSVLT VLHQDWLNGKEYK CKVSNKALPAPIEKTISKAKGQPRE PQVYTLPPSRDELTKNQVSLTCLVK GFYPSDIAVEWESNGQPENNYKTTP PVL DSDGSFFLYSKLTVDKSRWQQGNVF SCSVMHEALHNHY TQKSLSLSPGK |
Sequence Similarities : | Belongs to the type II cytokine receptor family.Contains 2 fibronectin type-III domains.Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
Gene Name : | IFNGR1 interferon gamma receptor 1 [ Homo sapiens ] |
Official Symbol : | IFNGR1 |
Synonyms : | IFNGR1; interferon gamma receptor 1; IFNGR; CD119; |
Gene ID : | 3459 |
mRNA Refseq : | NM_000416 |
Protein Refseq : | NP_000407 |
MIM : | 107470 |
Uniprot ID : | P15260 |
Chromosome Location : | 6q23-q24 |
Pathway : | Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; |
Function : | cytokine binding; interferon-gamma receptor activity; receptor activity; |
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IFNGR1-2029R | Recombinant Rhesus Macaque IFNGR1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IFNGR1-001H | Recombinant Human IFNGR1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IFNGR1-1003CCL | Recombinant Cynomolgus IFNGR1 cell lysate | +Inquiry |
IFNGR1-1775MCL | Recombinant Mouse IFNGR1 cell lysate | +Inquiry |
IFNGR1-1175RCL | Recombinant Rat IFNGR1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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