Active Recombinant Human IL34 protein, His-tagged
Cat.No. : | IL34-28245TH |
Product Overview : | Recombinant Human IL34 fused with His tag at C-terminal was expressed in HEK293. |
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- Gene Information
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Description : | IL-34 is a homodimeric cytokine that is expressed in a range of tissues including spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1 stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Bio-activity : | Measured by its ability to induce secretion of MCP-1 from PBMCs. |
Molecular Mass : | 52.5 kDa |
Protein length : | 460 amino acid residues |
AA Sequence : | NEPLEMWPL TQNEECTVT GFLRDKLQY RSRLQYMKH YFPINYKIS VPYEGVFRI ANVTRLQRA QVSERELRY LWVLVSLSA TESVQDVLL EGHPSWKYL QEVETLLLN VQQGLTDVE VSPKVESVL SLLNAPGPN LKLVRPKAL LDNCFRVME LLYCSCCKQ SSVLNWQDC EVPSPQSCS PEPSLQYAA TQLYPPPPW SPSSPPHST GSVRPVRAQ GEGLLPHHH HHHHH |
Purity : | Above 95% as determined by SDS-PAGE Analysis. |
Gene Name : | IL34 interleukin 34 [ Homo sapiens ] |
Official Symbol : | IL34 |
Synonyms : | IL34; interleukin 34; C16orf77, chromosome 16 open reading frame 77; interleukin-34; IL 34; MGC34647; IL-34; C16orf77; |
Gene ID : | 146433 |
mRNA Refseq : | NM_001172771 |
Protein Refseq : | NP_001166242 |
MIM : | 612081 |
UniProt ID : | Q6ZMJ4 |
Chromosome Location : | 16q22.1 |
Function : | cytokine activity; growth factor activity; macrophage colony-stimulating factor receptor binding; |
Products Types
◆ Recombinant Protein | ||
Il34-3522M | Active Recombinant Mouse Il34 Protein, His-tagged | +Inquiry |
IL34-2701R | Recombinant Rat IL34 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL34-053H | Recombinant Human IL34 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
IL34-2072R | Recombinant Rhesus Macaque IL34 Protein, His (Fc)-Avi-tagged | +Inquiry |
Il34-1864H | Recombinant Mouse Il34 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
IL34-2783MCL | Recombinant Mouse IL34 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere are no clear studies showing the effect of IL34 on tumor prognosis.
Can fight disease by modulating the immune system and may have better efficacy and fewer side effects than other treatments.
May inhibit tumor growth and metastasis by enhancing immune cells' ability to attack tumor cells.
No large-scale clinical trials have been reported, but some early studies have shown a potential therapeutic effect.
Regulate the function of macrophages and dendritic cells and affect the immune response of the immune system.
The evaluation of the efficacy of IL34 usually requires a comprehensive evaluation of clinical symptoms, biochemical indicators, imaging and other indicators.
Customer Reviews (3)
Write a reviewIL34 has shown good biocompatibility and safety in related experiments.
When using IL34 for experiments, the experimental conditions and results are highly repeatable.
Quality is stable and reliable, with no significant differences between batches.
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