"IL34" Related Products

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Recombinant Human IL34 protein, His-tagged

Cat.No.: IL34-28245TH
Product Overview: Recombinant Human IL34 fused with His tag at C-terminal was expressed in HEK293.
Description: IL-34 is a homodimeric cytokine that is expressed in a range of tissues including spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1 stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1.
Source: HEK293
Species: Human
Tag: His
Bio-activity: Measured by its ability to induce secretion of MCP-1 from PBMCs.
Molecular Mass: 52.5 kDa
Protein length: 460 amino acid residues
AA Sequence: NEPLEMWPL TQNEECTVT GFLRDKLQY RSRLQYMKH YFPINYKIS VPYEGVFRI ANVTRLQRA QVSERELRY LWVLVSLSA TESVQDVLL EGHPSWKYL QEVETLLLN VQQGLTDVE VSPKVESVL SLLNAPGPN LKLVRPKAL LDNCFRVME LLYCSCCKQ SSVLNWQDC EVPSPQSCS PEPSLQYAA TQLYPPPPW SPSSPPHST GSVRPVRAQ GEGLLPHHH HHHHH
Purity: Above 95% as determined by SDS-PAGE Analysis.
Gene Name: IL34 interleukin 34 [ Homo sapiens ]
Official Symbol: IL34
Synonyms: IL34; interleukin 34; C16orf77, chromosome 16 open reading frame 77; interleukin-34; IL 34; MGC34647; IL-34; C16orf77;
Gene ID: 146433
mRNA Refseq: NM_001172771
Protein Refseq: NP_001166242
MIM: 612081
UniProt ID: Q6ZMJ4
Chromosome Location: 16q22.1
Function: cytokine activity; growth factor activity; macrophage colony-stimulating factor receptor binding;

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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