"IL5" Related Products

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Recombinant Human IL5, His-tagged

Cat.No.: IL5-27607TH
Product Overview: Recombinant full length mature Human IL5 with His tag at N terminal produced in the endosperm tissue of barley grain ; 131 amino acids with tag, Predicted MWt 15.3 kDa.
Description: The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
Conjugation: HIS
Biological activity: Bioactivity is assayed by measuring the dose dependent effect of Human IL5 on proliferation of TF-1 cells. The EC50 for IL5-27607TH was determined to be 1.51 ng/ml, corresponding to 0.66x 106 U/mg.
Form: Lyophilised:Reconstitute the lyophilized protein in sterile water to a concentration of no less than 100 μg/ml. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: PBS, pH 7.2
Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
Sequence Similarities: Belongs to the IL-5 family.
Gene Name: IL5 interleukin 5 (colony-stimulating factor, eosinophil) [ Homo sapiens ]
Official Symbol: IL5
Synonyms: IL5; interleukin 5 (colony-stimulating factor, eosinophil); interleukin-5; B cell differentiation factor I; EDF; eosinophil differentiation factor; IL 5; interleukin 5; T cell replacing factor; TRF;
Gene ID: 3567
mRNA Refseq: NM_000879
Protein Refseq: NP_000870
MIM: 147850
Uniprot ID: P05113
Chromosome Location: 5q23-q31
Pathway: Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem;
Function: cytokine activity; growth factor activity; interleukin-5 receptor binding; protein binding;

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