||Recombinant fragment, corresponding to amino acids 21-236 of Human IL7R alpha fused to the Fc region of Human IgG1 expressed in modified Human 293 cells.
||The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
||Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not reco
||>95% by SDS-PAGE
||Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin, PBS
||Store at +4°C.
|Sequences of amino acids:
||Theoretical Sequence:ESGYAQNGDLEDAELDDYSFSCYSQLEVN GSQHSLTCAFEDPDVNITNLEFEICGALVEVKCLNFRK LQEIYFIETKKFLLIGKSNICVKVGEKSLTCKKIDLTTIV KPEAPFDLSVVYREGANDFVVTFNTSHLQKKYVKVLMH DVAYRQEKDENKWTHVNLSSTKLTLLQRKLQPAAMYEIKV RSIPDHYFKGFWSEWSPSYYFRTPEINNSSGGIPKVDK KVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTL MISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKP REEQYNSTYRVVSVLTVLHQDWLNGKEYKCRVSNKALP APIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY SKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSP GK
||Belongs to the type I cytokine receptor family. Type 4 subfamily.Contains 1 fibronectin type-III domain.