Recombinant Human IRAK4, GST-tagged

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Recombinant Human IRAK4, GST-tagged

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Cat.No. : IRAK4-26999TH
Product Overview : Recombinant full length IRAK4 protein (Human), was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag, MW 81 kDa.
Description : This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Conjugation : GST
Form : Liquid
Storage buffer : Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.Contains 1 death domain.Contains 1 protein kinase domain.
Gene Name : IRAK4 interleukin-1 receptor-associated kinase 4 [ Homo sapiens ]
Official Symbol : IRAK4
Synonyms : IRAK4; interleukin-1 receptor-associated kinase 4; NY REN 64;
Gene ID : 51135
mRNA Refseq : NM_001114182
Protein Refseq : NP_001107654
MIM : 606883
Uniprot ID : Q9NWZ3
Chromosome Location : 12q12
Pathway : Activated TLR4 signalling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem;
Function : ATP binding; interleukin-1 receptor binding; magnesium ion binding; nucleotide binding; protein binding;

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