Recombinant Human IRF2, His-tagged

• Cat.No.: IRF2-28272TH
• Product Overview: Recombinant fragment (with N terminal His-tag), from Human IRF2. Molecular Weight: 15 kDa (133 amino acids).

Specification

• Description: IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4.
• Conjugation: HIS
• Source: E. coli
• Tissue specificity: Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris, 1mM DTT, pH 8
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MPVERMRMRP WLEEQINSNT IPGLKWLNKE KKIFQIPWMH AARHGWDVEK DAPLFRNWAI HTGKHQPGVD KPDPKTWKAN FRCAMNSLPD IEEVKDKSIK KGNNAFRVYR MLP
• Sequence Similarities: Belongs to the IRF family.Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Gene Information

• Gene Name: IRF2 interferon regulatory factor 2 [ Homo sapiens ]
• Official Symbol: IRF2
• Synonyms: IRF2; interferon regulatory factor 2
• Gene ID: 3660
• mRNA Refseq: NM_002199
• Protein Refseq: NP_002190
• MIM: 147576
• Uniprot ID: P14316
• Chromosome Location: 4q34.1-q35.1
• Pathway: Apoptosis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Factors involved in megakaryocyte development and platelet production, organism-specific biosystem; Hemostasis, organism-specific biosystem; Immune System, organism-specific biosystem
• Function: DNA binding; protein binding; regulatory region DNA binding; sequence-specific DNA binding transcription factor activity