"IRF3" Related Products

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Recombinant Human IRF3

Cat.No.: IRF3-28273TH
Product Overview: Recombinant fragment, corresponding to amino acids 1-112 of Human IRF3.
Description: IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants have been described.
Source: E. coli
Tissue specificity: Expressed constitutively in a variety of tissues.
Form: Liquid
Purity: >95% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: PBS, pH 7.4
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids: MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKHGLRQDAQQED FGIFQAWAEA TGAYVPGRDK PDLPTWKRNFRSALNRKEGL RLAEDRSKDP HDPHKIYEFV NS
Sequence Similarities: Belongs to the IRF family.Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
Gene Name: IRF3 interferon regulatory factor 3 [ Homo sapiens ]
Official Symbol: IRF3
Synonyms: IRF3; interferon regulatory factor 3;
Gene ID: 3661
mRNA Refseq: NM_001197122
Protein Refseq: NP_001184051
MIM: 603734
Uniprot ID: Q14653
Chromosome Location: 19q13.3-q13.4
Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem; Apoptosis, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem;
Function: DNA binding; identical protein binding; protein binding; protein homodimerization activity; regulatory region DNA binding;

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