Recombinant Human IRF4
Cat.No. : | IRF4-28543TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 144-451 of Human MUM1, Q15306 |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. |
Source : | E. coli |
Tissue specificity : | Lymphoid cells. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequence Similarities : | Belongs to the IRF family.Contains 1 IRF tryptophan pentad repeat DNA-binding domain. |
Gene Name : | IRF4 interferon regulatory factor 4 [ Homo sapiens ] |
Official Symbol : | IRF4 |
Synonyms : | IRF4; interferon regulatory factor 4; MUM1; LSIRF; |
Gene ID : | 3662 |
mRNA Refseq : | NM_001195286 |
Protein Refseq : | NP_001182215 |
MIM : | 601900 |
Uniprot ID : | Q15306 |
Chromosome Location : | 6p25-p23 |
Pathway : | Apoptosis, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem; Immune System, organism-specific biosystem; |
Function : | regulatory region DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor binding; |
Products Types
◆ Recombinant Protein | ||
IRF4-5039H | Recombinant Human IRF4 Protein, GST-tagged | +Inquiry |
Irf4-3575M | Recombinant Mouse Irf4 Protein, Myc/DDK-tagged | +Inquiry |
IRF4-1197H | Recombinant Human IRF4 Protein, His (Fc)-Avi-tagged | +Inquiry |
IRF4-2119R | Recombinant Rhesus Macaque IRF4 Protein, His (Fc)-Avi-tagged | +Inquiry |
IRF4-2889H | Recombinant Human IRF4 Protein (Glu130-Glu451), N-His tagged | +Inquiry |
◆ Lysates | ||
IRF4-5165HCL | Recombinant Human IRF4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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