Recombinant Human IVL

• Cat.No.: IVL-28450TH
• Product Overview: Recombinant fragment, corresponding to amino acids 420-578 of Human Involucrin with proprietary tag; 159 amino acids, 41kDa.

Specification

• Description: Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase.This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
• Source: E. coli
• Tissue specificity: Keratinocytes of epidermis and other stratified squamous epithelia.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 50mM Tris acetate, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the involucrin family.

Gene Information

• Gene Name: IVL involucrin [ Homo sapiens ]
• Official Symbol: IVL
• Synonyms: IVL; involucrin
• Gene ID: 3713
• mRNA Refseq: NM_005547
• Protein Refseq: NP_005538
• MIM: 147360
• Uniprot ID: P07476
• Chromosome Location: 1q21
• Pathway: Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
• Function: protein binding, bridging; structural molecule activity