Recombinant Human KCNJ11
Cat.No. : | KCNJ11-29900TH |
Product Overview : | Recombinant fragment corresponding to amino acids 301-390 of Human Kir6.2 with an N terminal proprietary tag; Predicted MWt 35.53 kDa inclusive of tag. |
- Specification
- Gene Information
- Related Products
Description : | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. |
Protein length : | 90 amino acids |
Molecular Weight : | 35.530kDa inclusive of tags |
Source : | Wheat germ |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage buffer : | pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | RTSYLADEILWGQRFVPIVAEEDGR YSVDYSKFGNTVKVPTPLCTARQLD EDHSLLEALTLASARGPLRKRSVPM AKAKPKFSISPDSLS |
Gene Name : | KCNJ11 potassium inwardly-rectifying channel, subfamily J, member 11 [ Homo sapiens ] |
Official Symbol : | KCNJ11 |
Synonyms : | KCNJ11; potassium inwardly-rectifying channel, subfamily J, member 11; ATP-sensitive inward rectifier potassium channel 11; BIR; Kir6.2; |
Gene ID : | 3767 |
mRNA Refseq : | NM_000525 |
Protein Refseq : | NP_000516 |
MIM : | 600937 |
Uniprot ID : | Q14654 |
Chromosome Location : | 11p15.1 |
Pathway : | ATP sensitive Potassium channels, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Inwardly rectifying K+ channels, organism-specific biosystem; Metabolism, organism-specific biosystem; |
Function : | ATP binding; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; potassium ion binding; protein C-terminus binding; |
Products Types
◆ Recombinant Protein | ||
KCNJ11-2179R | Recombinant Rhesus Macaque KCNJ11 Protein, His (Fc)-Avi-tagged | +Inquiry |
KCNJ11-3193H | Recombinant Human KCNJ11 Protein, His (Fc)-Avi-tagged | +Inquiry |
KCNJ11-2852R | Recombinant Rat KCNJ11 Protein, His (Fc)-Avi-tagged | +Inquiry |
Kcnj11-3756R | Recombinant Rat Kcnj11, His-tagged | +Inquiry |
KCNJ11-2358R | Recombinant Rhesus monkey KCNJ11 Protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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