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Native Human KNG1

Cat.No. : KNG1-29338TH
Product Overview : Full length native Human HMW Kininogen from Human plasma, 120kDa.
  • Specification
  • Gene Information
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Description : This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
Source : Human Plasma
Species : Human
Form : Liquid
Molecular Mass : 120kDa
Purity : >95% by SDS-PAGE
Storage : Shipped on dry ice. Upon delivery aliquot and store at -20°C . Avoid freeze / thaw cycles.
Storage Buffer : Preservative: NoneConstituents: 250mM Sodium chloride, 10mM Sodium acetate, pH 5.5
Gene Name : KNG1 kininogen 1 [ Homo sapiens ]
Official Symbol : KNG1
Synonyms : KNG1; kininogen 1; BDK, kininogen , KNG; kininogen-1; alpha 2 thiol proteinase inhibitor; bradykinin; HMWK; fitzgerald factor; high molecular weight kininogen; alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor; BDK; KNG;
Gene ID : 3827
mRNA Refseq : NM_000893
Protein Refseq : NP_000884
MIM : 612358
UniProt ID : P01042
Chromosome Location : 3q21-qter
Pathway : ACE Inhibitor Pathway, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem;
Function : cysteine-type endopeptidase inhibitor activity; heparin binding; peptidase inhibitor activity; receptor binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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07/26/2021

    Utilizing protein reagents reduces material consumption in experiments, resulting in resource conservation.

    05/09/2019

      The usage method of protein reagents is flexible, adapting to various experimental requirements.

      01/06/2018

        The precise and reliable results achieved by employing protein reagents make them highly favored in scientific research.

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