Recombinant Human LAIR1

• Cat.No.: LAIR1-29001TH
• Product Overview: Recombinant fragment, corresponding to extracellular amino acids 22-125 of Human LAIR1, MW 11.7 kDa.

Specification

• Description: The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.
• Source: E. coli
• Tissue specificity: Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low ex
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 50mM Sodium chloride, 20mM Tris HCl, 1mM EDTA, pH 7.5
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Sequences of amino acids: MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPSESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG
• Sequence Similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Gene Information

• Gene Name: LAIR1 leukocyte-associated immunoglobulin-like receptor 1 [ Homo sapiens ]
• Official Symbol: LAIR1
• Synonyms: LAIR1; leukocyte-associated immunoglobulin-like receptor 1; leukocyte associated Ig like receptor 1; CD305
• Gene ID: 3903
• mRNA Refseq: NM_002287
• Protein Refseq: NP_002278
• MIM: 602992
• Uniprot ID: Q6GTX8
• Chromosome Location: 19q13.4
• Function: protein binding; receptor activity