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Recombinant Human LMNA

Cat.No. : LMNA-28299TH
Product Overview : Recombinant full length Human mature protein Lamin A, MW 70 kDa,
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  • Gene Information
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Description : The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Source : E. coli
Tissue specificity : In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle celle (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degener
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the intermediate filament family.
Gene Name : LMNA lamin A/C [ Homo sapiens ]
Official Symbol : LMNA
Synonyms : LMNA; lamin A/C; cardiomyopathy, dilated 1A (autosomal dominant) , CMD1A, lamin A/C like 1 , LGMD1B, limb girdle muscular dystrophy 1B (autosomal dominant) , LMN1, LMNL1, PRO1, progeria 1 (Hutchinson Gilford type); prelamin-A/C; HGPS;
Gene ID : 4000
mRNA Refseq : NM_005572
Protein Refseq : NP_005563
MIM : 150330
Uniprot ID : P02545
Chromosome Location : 1q22
Pathway : Activation of Chaperones by IRE1alpha, organism-specific biosystem; Adipogenesis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem;
Function : protein binding; structural molecule activity; structural molecule activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does LMNA interact with other structural proteins? 02/28/2021

LMNA interacts with various structural proteins, playing a key role in the nuclear architecture.

How do genetic variations in LMNA affect cellular mechanics? 10/27/2018

Genetic alterations in LMNA can impair the structural stability of the nucleus, affecting overall cell function.

What potential therapeutic applications arise from targeting LMNA-related disorders? 08/26/2018

Targeting LMNA mutations could offer therapeutic strategies for conditions like progeria and cardiac diseases.

What is the primary role of LMNA in cellular structure? 05/07/2018

LMNA, encoding lamin proteins, is vital for maintaining the structural integrity of the nucleus in cells.

How does LMNA contribute to nuclear envelope stability? 12/29/2017

It contributes to nuclear envelope stability, ensuring proper nuclear shape and mechanical support.

What role does LMNA play in genetic disorders like progeria? 08/01/2017

LMNA mutations are associated with progeria, leading to premature aging and related phenotypes.

What is the impact of altered LMNA activity on cardiovascular health? 07/17/2017

Altered LMNA activity is linked to cardiovascular diseases, influencing heart muscle function and structure.

Customer Reviews (3)

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Reviews
07/26/2022

    Efficient and precise. Enhances research quality.

    05/10/2022

      Crucial for research integrity. Trusted for insights.

      01/29/2018

        Dependable partner. Supports our research endeavors.

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