Recombinant Human LMNB1

• Cat.No.: LMNB1-28298TH
• Product Overview: Recombinant full length Human Lamin B1 with a N terminal proprietary tag; predicted MWt 90.53 kDa inclusive of tag

Specification

• Description: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).
• Protein length: 586 amino acids
• Molecular Weight: 90.530kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELN DRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKA LYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLN YAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLE GDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQS LTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEY KLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSE MNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACL ERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLN DYEQLLDVKLALDMEISAYRKLLQGEEERLKLSPSPSS RVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSA SATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRK IGDTSVSYKYTSRYVLKAGQTVTIWAANAGVTASPPTDLI WKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTIPE EEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM
• Sequence Similarities: Belongs to the intermediate filament family.

Gene Information

• Gene Name: LMNB1 lamin B1 [ Homo sapiens ]
• Official Symbol: LMNB1
• Synonyms: LMNB1; lamin B1; lamin-B1
• Gene ID: 4001
• mRNA Refseq: NM_001198557
• Protein Refseq: NP_001185486
• MIM: 150340
• Uniprot ID: P20700
• Chromosome Location: 5q23.2
• Pathway: Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Breakdown of the nuclear lamina, organism-specific biosystem; Caspase cascade in apoptosis, organism-specific biosystem
• Function: phospholipase binding; structural molecule activity