Recombinant Human MAP3K2

• Cat.No.: MAP3K2-30191TH
• Product Overview: Recombinant full length Human MEKK2 with an N-terminal proprietary tag, expressed by baculovirus in Sf9 insect cells. MW ~115kDa.

Specification

• Description: The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.
• Biological activity: Specific activity: 226nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Contains 1 OPR domain.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Homo sapiens ]
• Official Symbol: MAP3K2
• Synonyms: MAP3K2; mitogen-activated protein kinase kinase kinase 2; MEKK2; MAP/ERK kinase kinase 2; MEKK2B
• Gene ID: 10746
• mRNA Refseq: NM_006609
• Protein Refseq: NP_006600
• MIM: 609487
• Uniprot ID: Q9Y2U5
• Chromosome Location: 2q21.1
• Pathway: EGFR1 Signaling Pathway, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; Gap junction, organism-specific biosystem; Gap junction, conserved biosystem; GnRH signaling pathway, organism-specific biosystem
• Function: ATP binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein kinase activity