Recombinant Human MAP3K8

• Cat.No.: MAP3K8-29126TH
• Product Overview: Recombinant fragment corresponding to amino acids 30-397 of Human MAP3K8 with N-terminal proprietary tag expressed in a Baculovirus infected Sf9 cell expression system; 368 amino acids, MW 70kDa.

Specification

• Description: This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.
• Tissue specificity: Expressed in several normal tissues and human tumor-derived cell lines.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Contains 1 protein kinase domain.

Gene Information

• Gene Name: MAP3K8 mitogen-activated protein kinase kinase kinase 8 [ Homo sapiens ]
• Official Symbol: MAP3K8
• Synonyms: MAP3K8; mitogen-activated protein kinase kinase kinase 8; COT, ESTF; c COT; EST; MEKK8; Tpl 2
• Gene ID: 1326
• mRNA Refseq: NM_001244134
• Protein Refseq: NP_001231063
• MIM: 191195
• Uniprot ID: P41279
• Chromosome Location: 10p11.2
• Pathway: Adaptive Immune System, organism-specific biosystem; CD28 co-stimulation, organism-specific biosystem; CD28 dependent PI3K/Akt signaling, organism-specific biosystem; Costimulation by the CD28 family, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem
• Function: ATP binding; MAP kinase kinase kinase activity; magnesium ion binding; nucleotide binding; protein binding