Recombinant Human MAPK1
Cat.No. : | MAPK1-28697TH |
Product Overview : | Recombinant full length human ERK2 expressed in E. coli cells using an N-terminal tag. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. |
Source : | E. coli |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain. |
Gene Name : | MAPK1 mitogen-activated protein kinase 1 [ Homo sapiens ] |
Official Symbol : | MAPK1 |
Synonyms : | MAPK1; mitogen-activated protein kinase 1; PRKM1, PRKM2; ERK; ERK2; MAPK2; p41mapk; |
Gene ID : | 5594 |
mRNA Refseq : | NM_002745 |
Protein Refseq : | NP_002736 |
MIM : | 176948 |
Uniprot ID : | P28482 |
Chromosome Location : | 22q11.2 |
Pathway : | ALK1 signaling events, organism-specific biosystem; ARMS-mediated activation, organism-specific biosystem; ATF-2 transcription factor network, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; |
Function : | ATP binding; DNA binding; MAP kinase activity; RNA polymerase II carboxy-terminal domain kinase activity; mitogen-activated protein kinase kinase kinase binding; |
Products Types
◆ Recombinant Protein | ||
MAPK1-385H | Recombinant Human MAPK1 Protein, MYC/DDK-tagged | +Inquiry |
MAPK1-2008H | Recombinant Human MAPK1 Protein, GST-tagged | +Inquiry |
Mapk1-7394M | Recombinant Mouse Mapk1 protein(Met1-Ser358), His&GST-tagged | +Inquiry |
Mapk1-3937M | Recombinant Mouse Mapk1 Protein, Myc/DDK-tagged | +Inquiry |
MAPK1-7267H | Recombinant Human MAPK1 protein(Met1-Ser360), GST-tagged | +Inquiry |
◆ Lysates | ||
MAPK1-692HCL | Recombinant Human MAPK1 cell lysate | +Inquiry |
MAPK1-001MCL | Recombinant Mouse MAPK1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMAPK1 expression and activity levels can be used as biomarkers to assess cancer risk and prognosis.
MAPK1 inhibitors are being explored for potential use in non-cancer conditions, such as heart disease and neurodegenerative disorders.
MAPK1 is also implicated in various other diseases, including cardiovascular diseases and neurological disorders.
Yes, there are targeted therapies that aim to inhibit MAPK1, especially in cases where MAPK1 is overactive in cancer cells.
Yes, by assessing the MAPK1 status in a patient's cells, healthcare providers can develop personalized treatment plans.
Customer Reviews (3)
Write a reviewWhether it be troubleshooting issues, offering experimental guidance, or addressing any concerns, the manufacturer's technical support ensures that researchers have a reliable and knowledgeable resource to rely on.
In addition to its scientific merits, the manufacturer of MAPK1 protein stands out for its outstanding technical support.
The company provides a dedicated team of experts who are readily available to assist researchers throughout their experimental journey.
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