Recombinant Human MAPK8
Cat.No. : | MAPK8-29668TH |
Product Overview : | Recombinant fragment, corresponding to amino acids 2-383 of Human JNK1, with a N terminal proprietary tag. Mw: 71 kDa. |
- Specification
- Gene Information
- Related Products
Description : | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
Source : | E. coli |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 20% Glycerol, 0.05% Tween 20, 3mM DTT, 25mM Tris HCl, 100mM Sodium chloride, pH 8.0 |
Storage : | Shipped at 4°C. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.Contains 1 protein kinase domain. |
Gene Name : | MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens ] |
Official Symbol : | MAPK8 |
Synonyms : | MAPK8; mitogen-activated protein kinase 8; PRKM8; JNK; JNK1; JUN N terminal kinase; SAPK1; |
Gene ID : | 5599 |
mRNA Refseq : | NM_002750 |
Protein Refseq : | NP_002741 |
MIM : | 601158 |
Uniprot ID : | P45983 |
Chromosome Location : | 10q11 |
Pathway : | ATF-2 transcription factor network, organism-specific biosystem; Activated TLR4 signalling, organism-specific biosystem; Activation of BH3-only proteins, organism-specific biosystem; Activation of BIM and translocation to mitochondria, organism-specific biosystem; Activation of BMF and translocation to mitochondria, organism-specific biosystem; |
Function : | ATP binding; JUN kinase activity; MAP kinase activity; histone deacetylase binding; histone deacetylase regulator activity; |
Products Types
◆ Recombinant Protein | ||
MAPK8-1137H | Recombinant Human MAPK8 Protein (S2-E364), His tagged | +Inquiry |
Mapk8-3945M | Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged | +Inquiry |
MAPK8-2420H | Recombinant Human MAPK8 Protein, His-tagged | +Inquiry |
MAPK8-1136H | Recombinant Human MAPK8 Protein (S2-E364), Tag Free | +Inquiry |
MAPK8-781H | Recombinant Human MAPK8 protein(Met1-Arg427), GST-tagged | +Inquiry |
◆ Lysates | ||
MAPK8-4489HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
MAPK8-4488HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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