Recombinant Human MAPT
Cat.No. : | MAPT-30138TH |
Product Overview : | Recombinant full-length human tag-free Tau, 352 amino acids, 49kDa. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimers disease, Picks disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. |
Source : | E. coli |
Tissue specificity : | Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. |
Form : | Liquid |
Storage buffer : | Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM PMSF, pH 7.5 |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequence Similarities : | Contains 4 Tau/MAP repeats. |
Gene Name : | MAPT microtubule-associated protein tau [ Homo sapiens ] |
Official Symbol : | MAPT |
Synonyms : | MAPT; microtubule-associated protein tau; DDPAC, MAPTL; FLJ31424; FTDP 17; G protein beta1/gamma2 subunit interacting factor 1; MGC138549; microtubule associated protein tau; isoform 4; MSTD; MTBT1; MTBT2; PPND; tau; TAU; |
Gene ID : | 4137 |
mRNA Refseq : | NM_001123066 |
Protein Refseq : | NP_001116538 |
MIM : | 157140 |
Uniprot ID : | P10636 |
Chromosome Location : | 17q21 |
Pathway : | Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; |
Function : | SH3 domain binding; apolipoprotein E binding; enzyme binding; lipoprotein particle binding; microtubule binding; |
Products Types
◆ Recombinant Protein | ||
MAPT-13H | Recombinant Human Tau-441 (2N4R) Wild-Type Protein (Pre-formed Fibrils) | +Inquiry |
MAPT-2887H | Recombinant Human MAPT protein(1-441 aa, Tau217), C-His-tagged | +Inquiry |
MAPT-120H | Recombinant Human p-Tau181 Protein | +Inquiry |
MAPT-02C | Recombinant Cynomolgus MAPT Protein, His tagged | +Inquiry |
MAPT-2893H | Recombinant Human MAPT protein(1-441 aa)(acetyl K281), C-His-tagged | +Inquiry |
◆ Lysates | ||
MAPT-4478HCL | Recombinant Human MAPT 293 Cell Lysate | +Inquiry |
MAPT-4476HCL | Recombinant Human MAPT 293 Cell Lysate | +Inquiry |
MAPT-4477HCL | Recombinant Human MAPT 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThe degree of abnormal aggregation of MAMAP proteins can be assessed by a variety of methods, such as immunohistochemistry, immunofluorescence staining, Western blot, etc. These methods can detect and quantify abnormally aggregated MAPT proteins.
The MAPT protein is closely related to the nerve cytoskeleton. It is involved in regulating axon formation and maintenance, cytosolic flow, and the normal function of neurons by binding and stabilizing microtubules.
MAPT protein interacts with other proteins in the nervous system, such as α-synuclein, β-kinigin, etc. These interactions may be involved in regulating the structure and function of neurons.
Yes, the expression of MAPT protein is affected by a variety of regulatory mechanisms, including transcriptional regulation, splicing regulation, phosphorylation regulation, etc. These regulatory mechanisms are essential for maintaining normal MAPT protein levels and function.
Future research directions include further elucidating the mechanism of abnormal aggregation and phosphorylation of MAPT protein, exploring the pathogenesis of genetic diseases associated with MAPT gene, finding therapeutic strategies to intervene in abnormal aggregation of MATT, and developing biomarkers related to MAPT protein for early diagnosis and therapeutic monitoring.
The MAPT protein plays an important role in clinical diagnosis. By measuring the level of the MAPT protein in the blood or cerebrospinal fluid, it can help identify different types of neurodegenerative diseases, such as Alzheimer's disease and prefrontal temporal dementia.
Customer Reviews (3)
Write a reviewWestern-blot experiments using MAPT as a target have shown highly reproducible results.
This stability of MAPT is very good and can maintain its original properties even after multiple uses.
MAPT's purity and consistency make it a top choice for Western-blot experiments.
Ask a Question for All MAPT Products
Required fields are marked with *
My Review for All MAPT Products
Required fields are marked with *
Inquiry Basket