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Recombinant Human MAT2A, T7 -tagged

Cat.No. : MAT2A-28860TH
Product Overview : Recombinant full length protein: Human Methionine Adenosyltransferase II fuse to T7 tag at N-terminus.
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  • Gene Information
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Description : The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes.
Conjugation : T7
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: 0.002% Sodium AzideConstituents: 0.1% Triton X-100, 10mM Tris, pH 8.0
Storage : Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
Sequence Similarities : Belongs to the AdoMet synthase family.
Gene Name : MAT2A methionine adenosyltransferase II, alpha [ Homo sapiens ]
Official Symbol : MAT2A
Synonyms : MAT2A; methionine adenosyltransferase II, alpha; S-adenosylmethionine synthase isoform type-2; MATA2; MATII; SAMS2;
Gene ID : 4144
mRNA Refseq : NM_005911
Protein Refseq : NP_005902
MIM : 601468
Uniprot ID : P31153
Chromosome Location : 2p11.2
Pathway : Biological oxidations, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem;
Function : ATP binding; metal ion binding; methionine adenosyltransferase activity; nucleotide binding; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can alterations in MAT2A expression be linked to cancer development? 06/14/2022

Yes, dysregulation of MAT2A expression has been associated with certain cancers. Understanding its role in cancer metabolism could lead to targeted therapies.

Can MAT2A inhibition be a strategy for treating hypermethylation-related disorders? 03/08/2020

In theory, inhibiting MAT2A could alter cellular methylation patterns, making it a potential strategy for disorders characterized by abnormal methylation.

How is MAT2A involved in regulating cellular methylation patterns? 12/09/2018

MAT2A influences cellular methylation patterns by providing SAMe, a methyl donor essential for the methylation of proteins, lipids, and nucleic acids.

In what ways does MAT2A impact neurotransmitter synthesis, and how does this relate to neurological disorders? 11/28/2017

SAMe, produced by MAT2A, is a precursor for neurotransmitter synthesis. Altered MAT2A function may have implications for neurological disorders like depression and schizophrenia.

How does MAT2A influence DNA methylation, and what implications does this have for cancer treatment? 06/25/2016

MAT2A-derived SAMe is essential for DNA methylation. Aberrant DNA methylation is a hallmark of cancer, and targeting MAT2A may have implications for epigenetic cancer therapies.

Customer Reviews (3)

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Reviews
09/06/2021

    Its exceptional reliability and compatibility with various research methodologies make it an invaluable asset for scientists seeking to delve into protein-protein interactions, signaling pathways, and structural investigations.

    04/19/2018

      Incorporating the ARRB2A protein into research endeavors ensures accurate and comprehensive results, bringing us closer to unraveling the complexities of cellular processes.

      01/27/2017

        Its robust nature and stability make it suitable for imaging studies, providing researchers with a detailed understanding of the protein's structural characteristics.

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