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Recombinant Human MNDA, His-tagged

Cat.No.: MNDA-30037TH
Product Overview: Recombinant full length Human MNDA with N-terminal His Tag; 427aa, 47.9kDa.
Description: The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.
Protein length: 407 amino acids
Conjugation: HIS
Molecular Weight: 47.900kDa inclusive of tags
Source: E. coli
Tissue specificity: Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: pH: 8.00Constituents:10% Glycerol, 0.02% DTT, 0.32% Tris HCl
Storage: Please see Notes section
Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MVNEYKKILL LKGFELMDDY HFTSIKSLLA YDLGLTTKMQ EEYNRIKITD LMEKKFQGVA CLDKLIELAK DMPSLKNLVN NLRKEKSKVA KKIKTQEKAP VKKINQEEVG LAAPAPTARN KLTSEARGRI PVAQKRKTPN KEKTEAKRNK VSQEQSKPPG PSGASTSAAV DHPPLPQTSS STPSNTSFTP NQETQAQRQV DARRNVPQND PVTVVVLKAT APFKYESPEN GKSTMFHATV ASKTQYFHVK VFDINLKEKF VRKKVITISD YSECKGVMEI KEASSVSDFN QNFEVPNRII EIANKTPKIS QLYKQASGTM VYGLFMLQKK SVHKKNTIYE IQDNTGSMDV VGSGKWHNIK CEKGDKLRLF CLQLRTVDRK LKLVCGSHSF IKVIKAKKNK EGPMNVN
Sequence Similarities: Contains 1 DAPIN domain.Contains 1 HIN-200 domain.
Gene Name: MNDA myeloid cell nuclear differentiation antigen [ Homo sapiens ]
Official Symbol: MNDA
Synonyms: MNDA; myeloid cell nuclear differentiation antigen; PYHIN3;
Gene ID: 4332
mRNA Refseq: NM_002432
Protein Refseq: NP_002423
MIM: 159553
Uniprot ID: P41218
Chromosome Location: 1q22
Function: DNA binding;

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