Recombinant Human MST1R

• Cat.No.: MST1R-30956TH
• Product Overview: Recombinant fragment, corresponding to C terminal amino acids 983-1400 of Human RON was expressed by baculovirus in Sf9 insect cells using an N-terminal tag, 71kDa.

Specification

• Description: This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464).
• Biological activity: Specific activity was determined to be 81nmol/min/mg.
• Form: Liquid
• Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [ Homo sapiens ]
• Official Symbol: MST1R
• Synonyms: MST1R; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); PTK8, PTK8 protein tyrosine kinase 8 , RON; macrophage-stimulating protein receptor; CD136; CDw136
• Gene ID: 4486
• mRNA Refseq: NM_001244937
• Protein Refseq: NP_001231866
• MIM: 600168
• Uniprot ID: Q04912
• Chromosome Location: 3p21
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem; a6b1 and a6b4 Integrin signaling, organism-specific biosystem; amb2 Integrin signaling, organism-specific biosystem
• Function: ATP binding; macrophage colony-stimulating factor receptor activity; nucleotide binding; protein binding; receptor activity