Recombinant Human MUT

• Cat.No.: MUT-30098TH
• Product Overview: Recombinant full length Human Methylmalonyl Coenzyme A mutase with N terminal proprietary tag; Predicted MWt 108.61 kDa.

Specification

• Description: This gene encodes the mitochondrial enzyme methylmalonyl Coenzyme A mutase. In humans, the product of this gene is a vitamin B12-dependent enzyme which catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA, while in other species this enzyme may have different functions. Mutations in this gene may lead to various types of methylmalonic aciduria.
• Protein length: 750 amino acids
• Molecular Weight: 108.610kDa inclusive of tags
• Source: Wheat germ
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MLRAKNQLFLLSPHYLRQVKESSGSRLIQQRLLHQQQPLH PEWAALAKKQLKGKNPEDLIWHTPEGISIKPLYSKGDTMD LPEELPGVKPFTRGPYPTMYTFRPWTIRQYAGFSTVEESN KFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMA GVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLANFI VTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMK IIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYT LADGLEYSRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIA KMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTE QDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVK SARIARNTQIIIQEESGIPKVADPWGGSYMMECLTNDVYD AALKLINEIEEMGGMAKAVAEGIPKLRIEECAARRQARID SGSEVIVGVNKYQLEKEDTVEVLAIDNTSVRNRQIEKLKK IKSSRDQALAERCLAALTECAASGDGNILALAVDASRARC TVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSA IKRVHKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFAD LGFDVDIGPLFQTPREVAQQAVDADVHAVGVNTLAAGHKT LVPELIKELNSLGRPDILVMCGGVIPPQDYEFLFEVGVSN VFGPGTRIPKAAVQVLDDIEKCLEKKQQSV
• Sequence Similarities: Belongs to the methylmalonyl-CoA mutase family.Contains 1 B12-binding domain.

Gene Information

• Gene Name: MUT methylmalonyl CoA mutase [ Homo sapiens ]
• Official Symbol: MUT
• Synonyms: MUT; methylmalonyl CoA mutase; methylmalonyl Coenzyme A mutase; methylmalonyl-CoA mutase, mitochondrial
• Gene ID: 4594
• mRNA Refseq: NM_000255
• Protein Refseq: NP_000246
• MIM: 609058
• Uniprot ID: P22033
• Chromosome Location: 6p21
• Pathway: Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, organism-specific biosystem; Glyoxylate and dicarboxylate metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of lipids and lipoproteins, organism-specific biosystem
• Function: cobalamin binding; metal ion binding; methylmalonyl-CoA mutase activity