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Recombinant Human NAE1, His-tagged

Cat.No. : NAE1-26749TH
Product Overview : Recombinant full length Human APPBP1 with N terminal His tag; 557 amino acids with tag, Predicted MWt 62.7 kDa.
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  • Gene Information
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Description : The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
Protein length : 534 amino acids
Conjugation : HIS
Molecular Weight : 62.700kDa inclusive of tags
Source : E. coli
Tissue specificity : Ubiquitous in fetal tissues. Expressed throughout the adult brain.
Form : Liquid
Purity : >90% by SDS-PAGE
Storage buffer : pH: 8.00Constituents:0.32% Tris HCl, 0.03% DTT, 10% Glycerol, 1.17% Sodium chloride
Storage : Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHHSSGLVPRGSHMGSMAQLGKLLKEQKYDRQL RLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSF TIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELN SDVSGSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSL RLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPD NALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVI IAKYLAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENG APEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINI TKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSG KYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISE KELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMD NPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKL KSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTIAAFL GGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
Sequence Similarities : Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
Gene Name : NAE1 NEDD8 activating enzyme E1 subunit 1 [ Homo sapiens ]
Official Symbol : NAE1
Synonyms : NAE1; NEDD8 activating enzyme E1 subunit 1; amyloid beta precursor protein binding protein 1 , amyloid beta precursor protein binding protein 1, 59kDa , amyloid beta precursor protein binding protein 1, 59kD , APPBP1; NEDD8-activating enzyme E1 regulato
Gene ID : 8883
mRNA Refseq : NM_001018159
Protein Refseq : NP_001018169
MIM : 603385
Uniprot ID : Q13564
Chromosome Location : 16q22
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem;
Function : contributes_to NEDD8 activating enzyme activity; catalytic activity; nucleotide binding; protein binding; protein heterodimerization activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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