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Recombinant Human NCR1

Cat.No. : NCR1-27989TH
Product Overview : Recombinant fragment, corresponding to the extracellular Ig-like domain, amino acids 1-22/255 of Human NCR1
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  • Gene Information
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Description : Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene. NCR1 has also been designated as CD335 (cluster of differentiation 335).
Source : E. coli
Tissue specificity : Selectively expressed by both resting and activated NK cells.
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: PBS, 1mM EDTA, pH 7.4
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Sequences of amino acids : MQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINKVKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEEVTFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRX FGSYNNHAWSFPSEPVKLLV TGDIENTSLA PEDPTFSADT WGTYLLTTET GLQKDHALWD HTAQN
Sequence Similarities : Belongs to the natural cytotoxicity receptor (NCR) family.Contains 2 Ig-like (immunoglobulin-like) domains.
Gene Name : NCR1 natural cytotoxicity triggering receptor 1 [ Homo sapiens ]
Official Symbol : NCR1
Synonyms : NCR1; natural cytotoxicity triggering receptor 1; LY94, lymphocyte antigen 94 (mouse) homolog (activating NK receptor; NK p46); CD335; NK p46; NKP46;
Gene ID : 9437
mRNA Refseq : NM_001145457
Protein Refseq : NP_001138929
MIM : 604530
Uniprot ID : O76036
Chromosome Location : 19
Pathway : Natural killer cell mediated cytotoxicity, organism-specific biosystem; Natural killer cell mediated cytotoxicity, conserved biosystem;
Function : receptor activity; receptor signaling protein activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the significance of the expression level of NCR1 protein in cancer immunotherapy? 11/13/2022

In some cancer immunotherapies, the expression level of NCR1 protein may affect the efficacy of the treatment. High levels of NCR1 expression may predict a better prognosis.

What is the significance of gene knockout technology to inhibit NCR1 expression in the treatment of autoimmune diseases? 06/02/2022

Inhibition of NCR1 expression by gene knockout technology can alleviate the symptoms of autoimmune diseases and provide new ideas and methods for the treatment of autoimmune diseases.

Is it possible to regulate the expression level of NCR1 protein through pharmacological intervention? 03/22/2022

There are currently no drugs that directly target the NCR1 protein, but there are some drugs that can affect the activity of the immune system and thus indirectly affect the expression level of the NCR1 protein.

Are there polymorphisms in the NCR1 gene and are they involved in the development of certain diseases? 01/23/2021

Yes, there are polymorphisms in the NCR1 gene, some of which may increase an individual's susceptibility to certain diseases such as inflammatory diseases and autoimmune diseases.

Are there antibodies or drugs against the NCR1 protein? 11/13/2020

There are currently no specific antibodies or drugs against the NCR1 protein, but there are some studies that are exploring the development of therapies against the NCR1 protein.

How can the function and mechanism of NCR1 protein be studied? 12/05/2019

The function and mechanism of action of NCR1 protein can be studied by gene knockout or knockdown techniques. In addition, techniques such as protein spectroscopy can be used to identify proteins that interact with NCR1 proteins and their sites of action.

Customer Reviews (3)

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Reviews
09/28/2022

    In drug screening experiments, it was found that it had good selectivity for specific disease-related targets.

    03/28/2022

      It has been observed in cell culture experiment that it can promote the growth and proliferation of cells.

      03/04/2021

        It has a wide range of applications and can be used in various biological experiments.

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