Recombinant Human NGFR, Fc-tagged

• Cat.No.: NGFR-30619TH
• Product Overview: Recombinant fragment corresponding to amino acids 1-250 of Human p75 NGF Receptor fused to the Fc region of Human IgG1 expressed in modified Human 293 cells.

Specification

• Description: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
• Conjugation: Fc
• Biological activity: The ED50 of this chimera is typically 0.7 - 1.0 ug/ml as measured by its ability to neutralize beta NGF mediated proliferation of the human growth factor dependent TF-1 cell line.
• Form: Lyophilised:It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial. Following reconstitution short-term storage at 4°C is recommended, and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not rec
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Trehalose, 1% Human serum albumin, PBS
• Storage: Store at +4°C.
• Sequences of amino acids: Theoretical sequence:KEACPTGLYTHSGECCKACNLGEGV AQPC GANQTVCEPCLDSVTFSDVVSATEP CKPCTECVGLQSM SAPCVEADDAVCRCAYGYYQDETTG RCEACRVCEAGSGLV FSCQDKQNTVCEECPDGTYSDEANH VDPCLPCTVCEDT ERQLRECTRWADAECEEIPGRWITR STPPEGSDSTAPS TQEPEAPPEQDLIASTVAGVVTTVM GSSQPVVTRGTTDNG SSNTKVDKKVEPKSCDKTHTCPPCP APELLGGPSVFLF PPKPKDTLMISRTPEVTCVVVDVSH EDPEVKFNWYVDGVEVHNAKTKPRE EQYNSTYRVVSVLTVLHQDWLNGKE YKC KVSNKALPAPIEKTISKAKGQPREP QVYTLPPSRDELT KNQVSLTCLVKGFYPSDIAVEWESN GQPENNYKTTPPVLD SDGSFFLYSKLTVDKSRWQQGNVFS CSVMHEALHNHYT QKSLSLSPGK
• Sequence Similarities: Contains 1 death domain.Contains 4 TNFR-Cys repeats.

Gene Information

• Gene Name: NGFR nerve growth factor receptor [ Homo sapiens ]
• Official Symbol: NGFR
• Synonyms: NGFR; nerve growth factor receptor; nerve growth factor receptor (TNFR superfamily, member 16); tumor necrosis factor receptor superfamily member 16; CD271; low affinity nerve growth factor receptor; p75NTR; TNFR superfamily; member 16; TNFRSF16
• Gene ID: 4804
• mRNA Refseq: NM_002507
• Protein Refseq: NP_002498
• MIM: 162010
• Uniprot ID: P08138
• Chromosome Location: 17q21-q22
• Pathway: Axonal growth inhibition (RHOA activation), organism-specific biosystem; Axonal growth stimulation, organism-specific biosystem; Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem; Ceramide signalling, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem
• Function: death receptor activity; nerve growth factor binding; protein binding; receptor activity; signal transducer activity