Recombinant Human NMI, His-tagged

• Cat.No.: NMI-28771TH
• Product Overview: Recombinant full length Human N myc interactor with an N terminal His tag ; predicted mwt: 37.2 kDa

Specification

• Description: NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
• Protein length: 307 amino acids
• Conjugation: HIS
• Molecular Weight: 37.200kDa inclusive of tags
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH FLSVETPEND SQLSNISCSF QVSSKVPYEI QKGQALITFE KEEVAQNVVS MSKHHVQIKDV NLEVTAKPV PLNSGVRFQV YVEVSKMKIN MEADKDDTQQ ILKEHSPDEF IKDEQNKGLI DEITKKNIQLK KEIQKLETE LQEATKEFQI KEDIPETKMK VTEIPDTLRE DQMRDKLELS FSKSRNGGGE VDRVDYDRQS GSAVITFVEI GVADKILKKKEYPLYINQTC HRVTVSPYTE IHLKKYQIFSGTSKRTVLLT GMEGIQMDEE IVEDLINIHF QRAKNGGGEV DVVKCSLGQP HIAYFEE

Gene Information

• Gene Name: NMI N-myc (and STAT) interactor [ Homo sapiens ]
• Official Symbol: NMI
• Synonyms: NMI; N-myc (and STAT) interactor; N-myc-interactor
• Gene ID: 9111
• mRNA Refseq: NM_004688
• Protein Refseq: NP_004679
• MIM: 603525
• Uniprot ID: Q13287
• Chromosome Location: 2q23
• Pathway: IL-2 Signaling Pathway, organism-specific biosystem
• Function: nucleotide binding; protein binding; transcription cofactor activity