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Recombinant Human NOV

Cat.No.: NOV-27832TH
Product Overview: Recombinant full length protein, corresponding to amino acids 28/357 of precursor Human CCN3 protein
Description: The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development.
Source: E. coli
Tissue specificity: Expressed in bone marrow, thymic cells and nephroblastoma. Increased expression in Wilms tumor of the stromal type.
Form: Lyophilised:Reconstitute to 1mg/ml with distilled water.
Purity: >95% by SDS-PAGE
Storage: The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C.
Sequences of amino acids: MQVAATQRCP PQCPGRCPAT PPTCAPGVRA VLDGCSCCLV CARQRGESCS DLEPCDESSG LYCDRSADPS NQTGICTAVE GDNCVFDGVI YRSGEKFQPS CKFQCTCRDG QIGCVPRCQL DVLLPEPNCP APRKVEVPGE CCEKWICGPD EEDSLGGLTL AAYRPEATLG VEVSDSSVNC IEQTTEWTAC SKSCGMGFST RVTNRNRQCE MLKQTRLCMV RPCEQEPEQP TDKKGKKCLR TKKSLKAIHL QFKNCTSLHT YKPRFCGVCS DGRCCTPHNT KTIQAEFQCS PGQIVKKPVM VIGTCTCHTN CPKNNEAFLQ ELELKTTRGK M
Sequence Similarities: Belongs to the CCN family.Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 IGFBP N-terminal domain.Contains 1 TSP type-1 domain.Contains 1 VWFC domain.
Gene Name: NOV nephroblastoma overexpressed gene [ Homo sapiens ]
Official Symbol: NOV
Synonyms: NOV; nephroblastoma overexpressed gene; protein NOV homolog; CCN3; IGFBP9;
Gene ID: 4856
mRNA Refseq: NM_002514
Protein Refseq: NP_002505
MIM: 164958
Uniprot ID: P48745
Chromosome Location: 8q24.12
Pathway: Delta-Notch Signaling Pathway, organism-specific biosystem;
Function: growth factor activity; insulin-like growth factor binding;

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