"THPO" Related Products

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Recombinant Human Thrombopoietin

Cat. No. : THPO-176H
Description : Thrombopoietin (leukemia virus oncogene ligand, megakaryocyte growth and development factor), also known as THPO is a lineage-dominant hematopoietic cytokine. TPO is a glycoprotein hormone constitutively produced mainly by the liver and kidney and is the primary physiological regulator megakaryopoiesis and platelet production.
Source : NSO Cells.
Molecular Weight : The predicted molecular weight of Recombinant Human TPO is Mr 35 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 80-90 kDa.
State Of Matter : Lyophilized.
Biological Activity : The biological activity of Human Thrombopoietin is determined by the dose-dependent stimulation of the proliferation of human MO7e cells. The expected ED50 for this effect is 1.0-3.0 ng/ml.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : THPO thrombopoietin [ Homo sapiens ]
Synonyms : thrombopoietin nirs variant 1; megakaryocyte stimulating factor; MKCSF; c-mpl ligand; megakaryocyte colony-stimulating factor; MGDF; megakaryocyte growth and development factor; MPL ligand; myeloproliferative leukemia virus oncogene ligand; C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGC163194; Myeloproliferative leukemia virus oncogene ligand; Thrombopoietin; ML; TPO; MPLLG; THPO
Gene ID : 7066
mRNA Refseq : NM_000460
Protein Refseq : NP_000451
MIM : 600044
UniProt ID : P40225
Chromosome Location : 3q27
Pathway : Hematopoietic cell lineage
Function : cytokine activity; growth factor activity; hormone activity

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