Recombinant Human OCLN

• Cat.No.: OCLN-27766TH
• Product Overview: Recombinant full length Human Occludin with an N terminal proprietary tag; Predicted MWt 83.53 kDa inclusive of tag.

Specification

• Description: This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.
• Protein length: 522 amino acids
• Molecular Weight: 83.530kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.3% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MSSRPLESPPPYRPDEFKPNHYAPSNDIYGGEMHVRPMLS QPAYSFYPEDEILHFYKWTSPPGVIRILSMLIIVMCIAIF ACVASTLAWDRGYGTSLLGGSVGYPYGGSGFGSYGSGYGY GYGYGYGYGGYTDPRAAKGFMLAMAAFCFIAALVIFVTSV IRSEMSRTRRYYLSVIIVSAILGIMVFIATIVYIMGVNPT AQSSGSLYGSQIYALCNQFYTPAATGLYVDQYSYHYCVVD PQEAIAIVLGFMIIVAFALIIFFAVKTRRKMDRYDKSNIL WDKEHIYDEQPPNVEEWVKNVSAGTQDVPSPPSDYVERVD SPMAYSSNGKVNDKRFYPESSYKSTPVPEVVQELPLTSPV DDFRQPRYSSGGNFETPSKRAPAKGRAGRSKRTEQDHYET DYTTGGESCDELEEDWIREYPPITSDQQRQLYKRNFDTGL QEYKSLQSELDEINKELSRLDKELDDYREESEEYMAAADE YNRLKQVKGSADYKSKKNHCKQLKSKLSHIKKMVGDYDRQ KT
• Sequence Similarities: Belongs to the ELL/occludin family.Contains 1 MARVEL domain.

Gene Information

• Gene Name: OCLN occludin [ Homo sapiens ]
• Official Symbol: OCLN
• Synonyms: OCLN; occludin; tight junction protein occludin TM4 minus
• Gene ID: 100506658
• mRNA Refseq: NM_001205254
• Protein Refseq: NP_001192183
• MIM: 602876
• Uniprot ID: Q16625
• Chromosome Location: 5q13.1
• Pathway: Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Leukocyte transendothelial migration, organism-specific biosystem
• Function: protein binding; structural molecule activity; thiopurine S-methyltransferase activity