Recombinant Human ONECUT1

• Cat.No.: ONECUT1-29373TH
• Product Overview: Recombinant full length Human HNF6; amino acids 1-465, 465 amino acids, Predicted MWt 51 kDa.

Specification

• Description: The protein encoded by HNF6 is Transcriptional activator. Binds the consensus sequence 5-DHWATTGAYTWWD-3 on a varietyof gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.
• Protein length: 465 amino acids
• Molecular Weight: 51.000kDa
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 500 mM L-arginine, 300 mM guanidine-HCl, 50 mM HEPES, 5 mM cystamine, 5 mM cysteamine, 5 mM Calcium chloride, 3 mM DTT, pH 7.5
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Gene Information

• Gene Name: ONECUT1 one cut homeobox 1 [ Homo sapiens ]
• Official Symbol: ONECUT1
• Synonyms: ONECUT1; one cut homeobox 1; HNF6, HNF6A, one cut domain, family member 1; hepatocyte nuclear factor 6; HNF 6
• Gene ID: 3175
• mRNA Refseq: NM_004498
• Protein Refseq: NP_004489
• MIM: 604164
• Uniprot ID: Q9UBC0
• Chromosome Location: 15q21.3
• Pathway: Developmental Biology, organism-specific biosystem; FOXM1 transcription factor network, organism-specific biosystem; Maturity onset diabetes of the young, organism-specific biosystem; Maturity onset diabetes of the young, conserved biosystem; Regulation of beta-cell development, organism-specific biosystem
• Function: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity