Description : |
This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These catalytic domains work sequentially to catalyze neuroendocrine peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene but some of their full length sequences are not yet known. |
Protein length : |
866 amino acids |
Molecular Weight : |
121.260kDa inclusive of tags |
Source : |
Wheat germ |
Form : |
Liquid |
Purity : |
Proprietary Purification |
Storage buffer : |
pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl |
Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : |
MAGRVPSLLVLLVFPSSCLAFRSPLSVFKRFKETTRPFSN ECLGTTRPVVPIDSSDFALDIRMPGVTPKQSDTYFCMSMR IPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSSTGSYWF CDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSK YFVLQVHYGDISAFRDNNKDCSGVSLHLTRLPQPLIAGMY LMMSVDTVIPAGEKVVNSDISCHYKNYPMHVFAYRVHTHH LGKVVSGYRVRNGQWTLIGRQSPQLPQAFYPVGHPVDVSF GDLLAARCVFTGEGRTEATHIGGTSSDEMCNLYIMYYMEA KHAVSFMTCTQNVAPDMFRTIPPEANIPIPVKSDMVMMHE HHKETEYKDKIPLLQQPKREEEEVLDQDFHMEEALDWPGV YLLPGQVSGVALDPKNNLVIFHRGDHVWDGNSFDSKFVYQ QIGLGPIEEDTILVIDPNNAAVLQSSGKNLFYLPHGLSID KDGNYWVTDVALHQVFKLDPNNKEGPVLILGRSMQPGSDQ NHFCQPTDVAVDPGTGAIYVSDGYCNSRIVQFSPSGKFIT QWGEESSGSSPLPGQFTVPHSLALVPLLGQLCVADRENGR IQCFKTDTKEFVREIKHSSFGRNVFAISYIPGLLFAVNGK PHFGDQEPVQGFVMNFSNGEIIDIFKPVRKHFDMPHDIVA SEDGTVYIGDAHTNTVWKFTLTEKLEHRSVKKAGIEVQEI KEAEAVVETKMENKPTSSELQKMQEKQKLIKEPGSGVPVV LITTLLVIPVVVLLAIAIFIRWKKSRAFGDSEHKLETSSG RVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRLSTEGSD QEKEDDGSESEEEYSAPLPALAPSSS |
Sequence Similarities : |
In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.Contains 5 NHL repeats. |