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Recombinant Human PAX3, GST-tagged

Cat.No. : PAX3-29056TH
Product Overview : Recombinant Human PAX3 (1 a.a. - 484 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.
  • Specification
  • Gene Information
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Description : This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 79.9 kDa
AA Sequence : MTTLAGAVPRMMRPGPGQNYPRSGF PLEVSTPLGQGRVNQLGGVFINGRP LPNHIRHKIVEMAHHGIRPCVISRQ LRVSHGCVSKILCRYQETGSIRPGA IGGSKPKQVTTPDVEKKIEEYKREN PGMFSWEIRDKLLKDAVCDRNTVPS VSSISRILRSKFGKGEEEEADLERK EAEESEKKAKHSIDGILSERASAPQ SDEGSDIDSEPDLPLKRKQRRSRTT FTAEQLEELERAFERTHYPDIYTRE ELAQRAKLTEARVQVWFSNRRARWR KQAGANQLMAFNHLIPGGFPPTAMP TLPTYQLSETSYQPTSIPQAVSDPS STVHRPQPLPPSTVHQSTIPSNPDS SSAYCLPSTRHGFSSYTDSFVPPSG PSNPMNPTIGNGLSPQVMGLLTNHG GVPHQPQTDYALSPLTGGLEPTTTV SASCSQRLDHMKSLDSLPTSQSYCP PTYSTTGYSMDPVTGYQYGQYGQSA FHYLKPDIA
Applications : ELISA; WB-Re; AP; Array
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : PAX3 paired box 3 [ Homo sapiens (human) ]
Official Symbol : PAX3
Synonyms : PAX3; WS1; WS3; CDHS; HUP2; paired box 3; paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; paired box homeotic gene 3
Gene ID : 5077
mRNA Refseq : NM_181458
Protein Refseq : NP_852123
MIM : 606597
UniProt ID : P23760
Chromosome Location : 2q35
Pathway : Neural Crest Differentiation; Regulation of retinoblastoma protein; Transcriptional misregulation in cancer
Function : HMG box domain binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; chromatin binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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