"TNFRSF1A" Related Products


Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 1A

Cat. No. : TNFRSF1A-1577H
Product Overview : Recombinant Human TNF receptor (P55) extracellular domain is produced in genetically engineeredSpodoptera frugiperda insect cells (Sf9)infected with recombinant viruses, and purified by sequential chromatography.
Description : TNFR1 belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-alpha or TNF-beta to TNFR1 initiates a signal transduction pathway that results in the activation of the transduction factor NFkB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis.
Source : Sf9.
Availability : Check availability.
Isotype : N/A.
Purity : Over 80% pure. Three bands are observed by SDS gel electrophoresis, however, a single band is observed after glycosidase treatment, indicating heterogeneity in the sugar portion of this glycoprotein.
Formulation : 10 mM Hepes, pH 7.0. Concentration: 1.0 mg protein/ml.
Biological Activity : Binding of the ligand TNF was demonstrated by receptor binding competition of binding with radioactive TNF.
Stability : At least 2 months at -80°C.
Storage : Store at -80°C.
Gene Name : TNFRSF1A tumor necrosis factor receptor superfamily, member 1A [ Homo sapiens ]
Synonyms : TNFRSF1A; tumor necrosis factor receptor superfamily, member 1A; FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55; MGC19588; tumor necrosis factor binding protein 1; tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; tumor necrosis factor receptor type 1; tumor necrosis factor-alpha receptor
Gene ID : 7132
mRNA Refseq : NM_001065
Protein Refseq : NP_001056
MIM : 191190
UniProt ID : P19438
Chromosome Location : 12p13.2
Pathway : Adipocytokine signaling pathway; Alzheimer"s disease; Amyotrophic lateral sclerosis (ALS); Apoptosis; Cytokine-cytokine receptor interaction; MAPK signaling pathway; MAPK signaling pathway; Apoptosis
Function : protein complex binding; receptor activity; tumor necrosis factor receptor activity

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