Recombinant Human PDCD6IP, His-tagged

• Cat.No.: PDCD6IP-27933TH
• Product Overview: Recombinant fragment, corresponding to amino acids 1-392 of Human PDC6I fused to His tag at N-terminus; 412 amino acids with tag, 45.8kDa.

Specification

• Description: This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MATFISVQLK KTSEVDLAKP LVKFIQQTYP SGGEEQAQYC RAAEELSKLR RAAVGRPLDK HEGALETLLR YYDQICSIEP KFPFSENQIC LTFTWKDAFD KGSLFGGSVK LALASLGYEK SCVLFNCAAL ASQIAAEQNL DNDEGLKIAA KHYQFASGAF LHIKETVLSA LSREPTVDIS PDTVGTLSLI MLAQAQEVFF LKATRDKMKD AIIAKLANQA ADYFGDAFKQ CQYKDTLPKE VFPVLAAKHC IMQANAEYHQ SILAKQQKKF GEEIARLQHA AELIKTVASR YDEYVNVKDF SDKINRALAA AKKDNDFIYH DRVPDLKDLD PIGKATLVKS TPVNVPISQK FTDLFEKMVP VSVQQSLAAY NQRKADLVNR SIAQMREATT LA
• Sequence Similarities: Contains 1 BRO1 domain.

Gene Information

• Gene Name: PDCD6IP programmed cell death 6 interacting protein [ Homo sapiens ]
• Official Symbol: PDCD6IP
• Synonyms: PDCD6IP; programmed cell death 6 interacting protein; programmed cell death 6-interacting protein; AIP1; ALG 2 interacting protein X; Alix; Hp95
• Gene ID: 10015
• mRNA Refseq: NM_001162429
• Protein Refseq: NP_001155901
• MIM: 608074
• Uniprot ID: Q8WUM4
• Chromosome Location: 3p22.3
• Pathway: Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem
• Function: calcium-dependent protein binding; protein binding