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Recombinant Human PDK4, His-tagged

Cat.No. : PDK4-29137TH
Product Overview : Recombinant full length Human PDK4 with His tag..
  • Specification
  • Gene Information
  • Related Products
Description : This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.
Protein length : 401 amino acids
Conjugation : HIS
Source : E. coli
Tissue specificity : Ubiquitous; highest levels of expression in heart and skeletal muscle.
Biological activity : Suppl ans:T7 promoter-driven (pET, Novagen) IPTG-inducible E. coli expression system.PDK4 was purified by metal chelation column chromatography (Ni-IDA) using His.Bind Columns (Novagen).PDK4 activity was measured in a serial dilution of the recombinant pr
Form : Liquid
Storage buffer : pH: 7.50Constituents:0.14% Sodium phosphate, 1.46% Sodium chloride, 30% Glycerol, 0.08% DTT, 0.02% EDTA, 0.05% Triton-X-100
Storage : Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities : Belongs to the PDK/BCKDK protein kinase family.Contains 1 histidine kinase domain.
Gene Name : PDK4 pyruvate dehydrogenase kinase, isozyme 4 [ Homo sapiens ]
Official Symbol : PDK4
Synonyms : PDK4; pyruvate dehydrogenase kinase, isozyme 4; pyruvate dehydrogenase kinase, isoenzyme 4;
Gene ID : 5166
mRNA Refseq : NM_002612
Protein Refseq : NP_002603
MIM : 602527
Uniprot ID : Q16654
Chromosome Location : 7q21.3-q22.1
Pathway : Metabolism, organism-specific biosystem; Pyruvate metabolism, organism-specific biosystem; Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem; Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystem; TCA Cycle, organism-specific biosystem;
Function : ATP binding; nucleotide binding; protein kinase activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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