Recombinant Human PDPN, His-tagged

• Cat.No.: PDPN-28603TH
• Product Overview: Recombinant fragment of Human Podoplanin / gp36 (amino acids 23-131) with N terminal His tag; 130 aa, 13.4kDa.

Specification

• Description: This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.
• Protein length: 109 amino acids
• Conjugation: HIS
• Molecular Weight: 13.400kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in colorectal tumors a
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: pH: 7.50Constituents:0.32% Tris HCl, 0.58% Sodium chloride
• Storage: Please see Notes section
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MASTGQPEDD TETTGLEGGV AMPGAEDDVV TPGTSEDRYK SGLTTLVATS VNSVTGIRIE DLPTSESTVH AQEQSPSATA SNVATSHSTE KVDGDTQTTV EKDGLSTVTL
• Sequence Similarities: Belongs to the podoplanin family.

Gene Information

• Gene Name: PDPN podoplanin [ Homo sapiens ]
• Official Symbol: PDPN
• Synonyms: PDPN; podoplanin; aggrus; Gp38; GP40; lung type I cell membrane associated glycoprotein; PA2.26; T1A 2
• Gene ID: 10630
• mRNA Refseq: NM_001006624
• Protein Refseq: NP_001006625
• MIM: 608863
• Uniprot ID: Q86YL7
• Chromosome Location: 1p36.21
• Function: NOT amino acid transmembrane transporter activity; NOT folic acid transporter activity; NOT water channel activity; NOT water transmembrane transporter activity