Recombinant Human PEA15

• Cat.No.: PEA15-30834TH
• Product Overview: Recombinant full length Human PEA15; amino acids 1-130 , 15kDa.

Specification

• Description: This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.
• Source: E. coli
• Tissue specificity: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose-producing tissues. Higher levels of expression are found in tissues from individuals wi
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 10% Glycerol, 20mM Tris HCl, 1mM DTT, pH 7.5
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA
• Sequence Similarities: Contains 1 DED (death effector) domain.

Gene Information

• Gene Name: PEA15 phosphoprotein enriched in astrocytes 15 [ Homo sapiens ]
• Official Symbol: PEA15
• Synonyms: PEA15; phosphoprotein enriched in astrocytes 15; astrocytic phosphoprotein PEA-15; HMAT1; homolog of mouse MAT 1 oncogene; HUMMAT1H; MAT1; MAT1H; PEA 15; PED; Phosphoprotein enriched in astrocytes; 15kD
• Gene ID: 8682
• mRNA Refseq: NM_003768
• Protein Refseq: NP_003759
• MIM: 603434
• Uniprot ID: Q15121
• Chromosome Location: 1q21.1
• Function: protein binding