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Recombinant Human PGK1

Cat.No. : PGK1-30891TH
Product Overview : Recombinant full length protein: , corresponding to amino acids 1-417 of Human PGK1
  • Specification
  • Gene Information
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Description : The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19.
Source : E. coli
Form : Liquid
Purity : >95% by SDS-PAGE
Storage buffer : Preservative: NoneConstituents: 10% Glycerol, 20mM Tris, 1mM DTT, pH 8
Storage : Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequences of amino acids : MGSSHHHHHH SSGLVPRGSH MSLSNKLTLD KLDVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKFC LDNGAKSVVL MSHLGRPDGV PMPDKYSLEP VAVELKSLLG KDVLFLKDCV GPEVEKACAN PAAGSVILLE NLRFHVEEEG KGKDASGNKV KAEPAKIEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPQKAGGFLM KKELNYFAKA LESPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM AFTFLKVLNN MEIGTSLFDE EGAKIVKDLM SKAEKNGVKI TLPVDFVTAD KFDENAKTGQ ATVASGIPAG WMGLDCGPES SKKYAEAVTR AKQIVWNGPV GVFEWEAFAR GTKALMDEVV KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKVLPG VDALSNI
Sequence Similarities : Belongs to the phosphoglycerate kinase family.
Gene Name : PGK1 phosphoglycerate kinase 1 [ Homo sapiens ]
Official Symbol : PGK1
Synonyms : PGK1; phosphoglycerate kinase 1;
Gene ID : 5230
mRNA Refseq : NM_000291
Protein Refseq : NP_000282
MIM : 311800
Uniprot ID : P00558
Chromosome Location : Xq13.3
Pathway : Gluconeogenesis, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, organism-specific biosystem; Gluconeogenesis, oxaloacetate => fructose-6P, conserved biosystem;
Function : ATP binding; nucleotide binding; phosphoglycerate kinase activity; phosphoglycerate kinase activity; transferase activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is PGK1 linked to neurological disorders? 06/27/2019

PGK1 dysfunction has been associated with neurological conditions like Alzheimer's disease and Parkinson's disease due to its impact on cellular energy metabolism.

In what way does PGK1 affect cancer? 11/29/2018

PGK1 is often upregulated in cancer cells, aiding their rapid growth and proliferation by enhancing glycolysis, known as the Warburg effect.

Can PGK1 be a target for cancer treatment? 09/17/2018

Research suggests that targeting PGK1 could potentially be a strategy for cancer therapy by disrupting the energy production in cancer cells.

Are there any PGK1 inhibitors or activators in development for clinical use? 01/11/2018

Several compounds that modulate PGK1 activity are being studied, but none have reached widespread clinical use yet.

Are there diagnostic uses for PGK1 in cancer? 01/17/2016

Yes, elevated levels of PGK1 have been identified in certain cancers, making it a potential biomarker for cancer detection and prognosis.

Customer Reviews (3)

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03/14/2020

    manufacturers may offer customization options, allowing researchers to tailor the PGK1 protein to their specific needs.

    02/27/2020

      This may include options like different formulations, protein modifications, or tagging techniques. Customization can enhance the versatility of the protein and optimize its utility in the intended research.

      04/15/2016

        They can also address any questions or concerns regarding the PGK1 protein, thereby facilitating smooth and efficient research execution.

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