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Recombinant Human PIM1

Cat.No.: PIM1-30290TH
Product Overview: Recombinant full length PIM1 protein (Human), was expressed by baculovirus in Sf9 insect cells using a N-terminal tag, MW 62kDa.
Description: The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
Tissue specificity: Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines.
Form: Liquid
Purity: >90% by SDS-PAGE
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily.Contains 1 protein kinase domain.
Gene Name: PIM1 pim-1 oncogene [ Homo sapiens ]
Official Symbol: PIM1
Synonyms: PIM1; pim-1 oncogene; PIM; proto-oncogene serine/threonine-protein kinase pim-1;
Gene ID: 5292
mRNA Refseq: NM_001243186
Protein Refseq: NP_001230115
MIM: 164960
Uniprot ID: P11309
Chromosome Location: 6p21
Pathway: Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; C-MYB transcription factor network, organism-specific biosystem; IL-5 Signaling Pathway, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem;
Function: ATP binding; manganese ion binding; metal ion binding; nucleotide binding; protein binding;

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