Recombinant Human PIN1, His-tagged

• Cat.No.: PIN1-29590TH
• Product Overview: Fusion protein, corresponding to amino acids 1-163 of Human Pin1.This protein contains a T7 tag at the N-terminus.

Specification

• Description: Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimers disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.
• Conjugation: HIS
• Source: E. coli
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: 0.02% Sodium AzideConstituents: 300mM Sodium chloride, 10mM HEPES, 1mM DTT, 1mM EDTA, pH 7.4
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Contains 1 PpiC domain.Contains 1 WW domain.

Gene Information

• Gene Name: PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [ Homo sapiens ]
• Official Symbol: PIN1
• Synonyms: PIN1; peptidylprolyl cis/trans isomerase, NIMA-interacting 1; protein (peptidyl prolyl cis/trans isomerase) NIMA interacting 1; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; dod
• Gene ID: 5300
• mRNA Refseq: NM_006221
• Protein Refseq: NP_006212
• MIM: 601052
• Uniprot ID: Q13526
• Chromosome Location: 19p13
• Pathway: C-MYC pathway, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem; RIG-I-like receptor signaling pathway, organism-specific biosystem
• Function: GTPase activating protein binding; isomerase activity; mitogen-activated protein kinase kinase binding; peptidyl-prolyl cis-trans isomerase activity; peptidyl-prolyl cis-trans isomerase activity