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Recombinant Human SOD1 protein

Cat.No. : SOD1-04H
Product Overview : Recombinant Human SOD1 protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
  • Related Products
Description : Superoxide dismutase catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. Cu/Zn superoxide dismutase also named as SOD1, is an enzyme encoded by the SOD1 gene in humans, located on chromosome 21. The SOD1 binds Cu and Zn ions and is one of three SODs responsible for destroying free superoxide radicals in the body. It has been shown to interact with CCS and Bcl-2. The malfunction of SOD1 may increase the risk of illnesses like age-related muscle mass loss (sarcopenia), early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, shortened lifespan, keratoconus and amyotrophic lateral sclerosis.
Source : E.coli
Species : Human
Form : Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4.
Bio-activity : Fully biologically active when compared to standard. The potency per mg was determined by Pyrogallic Acid method and was found to be more than 1.0 × 10⁴ IU/mg.
Molecular Mass : Approximately 31.6 kDa, a homodimer, non-glycosylated polypeptide chain containing 2 × 153 amino acids.
Protein length : 153
AA Sequence : ATKAVCVLKGDGPVQGIINFEQKES NGPVKVWGSIKGLTEGLHGFHVHEF GDNTAGCTSAGPHFNPLSRKHGGPK DEERHVGDLGNVTADKDGVADVSIE DSVISLSGDHCIIGRTLVVHEKADD LGKGGNEESTKTGNAGSRLACGVIG IAQ
Endotoxin : Less than 1 EU/μg of rHuCu/Zn SOD as determined by LAL method.
Purity : >95% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : SOD1
Official Symbol : SOD1
Synonyms : SOD1; superoxide dismutase 1, soluble; ALS, ALS1, amyotrophic lateral sclerosis 1 (adult); superoxide dismutase [Cu-Zn]; IPOA; SOD, soluble; indophenoloxidase A; Cu/Zn superoxide dismutase; superoxide dismutase, cystolic; ALS; SOD; ALS1; hSod1; homodimer;
Gene ID : 6647
mRNA Refseq : NM_000454
Protein Refseq : NP_000445
MIM : 147450
UniProt ID : P00441

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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Are there potential therapeutic strategies targeting SOD1 for disease treatment? 01/23/2022

Therapeutic strategies may involve modulating SOD1 activity or expression to mitigate oxidative stress-related damage.

What is the primary biological function of SOD1 in cells? 01/03/2022

SOD1 acts as an antioxidant, converting superoxide radicals to hydrogen peroxide and oxygen.

What are the genetic implications of mutations in the SOD1 gene? 03/01/2021

Mutations in SOD1 can result in loss or gain of function, contributing to disease development.

How is SOD1 implicated in neurodegenerative diseases? 02/09/2020

SOD1 mutations are implicated in Amyotrophic Lateral Sclerosis (ALS), leading to neurodegeneration.

In which cellular compartments is SOD1 primarily located? 11/14/2019

SOD1 is primarily located in the cytoplasm and mitochondrial intermembrane space.

What role does SOD1 play in maintaining cellular redox balance? 08/27/2019

It helps maintain cellular redox balance, protecting cells from oxidative damage.

How does SOD1 contribute to the cellular antioxidant defense system? 02/27/2019

It plays a crucial role in cellular defense against oxidative stress.

Customer Reviews (3)

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Reviews
11/15/2022

    Worked perfectly, no problems.

    10/09/2020

      Quick delivery, fantastic product.

      10/02/2020

        Reliable results every time.

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